AirHint found the following cheapest return flights from San Francisco (SFO) to Prague (PRG) in October 2025 (see full year).

Return flights

13 Oct - 01 Nov	Scandinavian Airlines
21 Oct - 03 Nov	Scandinavian Airlines
09 Oct - 22 Oct	Scandinavian Airlines
27 Oct - 03 Nov	Scandinavian Airlines
07 Oct - 21 Oct	Scandinavian Airlines
01 Oct - 15 Oct	Condor
01 Oct - 06 Oct	Scandinavian Airlines
05 Oct - 09 Oct	Condor
05 Oct - 12 Oct	Condor
01 Oct - 25 Oct	Condor
15 Oct - 18 Oct	Scandinavian Airlines
03 Oct - 18 Oct	Scandinavian Airlines
04 Oct - 18 Oct	TAP

Also check the deals for one-way flights from San Francisco to Prague in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from San Francisco to Prague in October from 398€

Return flights