AirHint found the following cheapest return flights from San Francisco (SFO) to Istanbul (IST) in October 2025 (see full year).

Return flights

06 Oct - 13 Oct	TAP
01 Oct - 08 Oct	Virgin Atlantic
13 Oct - 27 Oct	SWISS
01 Oct - 15 Oct	Hawaiian Airlines
12 Oct - 19 Oct	Hawaiian Airlines
08 Oct - 16 Oct	Frontier Airlines
01 Oct - 05 Oct	Hawaiian Airlines
02 Oct - 16 Oct	TAP
09 Oct - 16 Oct	TAP
01 Oct - 08 Oct	Turkish Airlines	direct
23 Oct - 06 Nov	Turkish Airlines	direct
30 Oct - 13 Nov	KLM
26 Oct - 09 Nov	Air France
26 Oct - 09 Nov	Turkish Airlines	direct
29 Oct - 24 Nov	Delta

Also check the deals for one-way flights from San Francisco to Istanbul in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from San Francisco to Istanbul in October from 505€

Return flights