AirHint found the following cheapest return flights from Santo Domingo (SDQ) to Panama City (PTY) in December 2025 (see full year).

Return flights

22 Dec - 15 Jan	Avianca
09 Dec - 16 Dec	Avianca
11 Dec - 15 Dec	Avianca
30 Dec - 01 Jan	Avianca
11 Dec - 16 Dec	Avianca
22 Dec - 15 Jan	Copa	direct
30 Dec - 06 Jan	Copa	direct
30 Dec - 12 Jan	Copa	direct
09 Dec - 06 Jan	Avianca
28 Dec - 04 Jan	Copa	direct
05 Dec - 11 Dec	Arajet
11 Dec - 18 Dec	Avianca
05 Dec - 12 Dec	Arajet
04 Dec - 15 Dec	Avianca
02 Dec - 06 Dec	Avianca
11 Dec - 15 Dec	Copa	direct
09 Dec - 06 Jan	Copa	direct
09 Dec - 05 Jan	Copa	direct
06 Dec - 14 Dec	Wingo
30 Dec - 01 Jan	Copa	direct

Also check the deals for one-way flights from Santo Domingo to Panama City in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Santo Domingo to Panama City in December from 422€

Return flights