AirHint found the following cheapest return flights from Santiago (SCQ) to Prague (PRG) in September 2025 (see full year).

Return flights

16 Sep - 22 Sep	Ryanair
20 Sep - 24 Sep	Ryanair
30 Sep - 04 Oct	Ryanair
18 Sep - 21 Sep	Vueling Airlines
23 Sep - 30 Sep	Ryanair
19 Sep - 22 Sep	Ryanair
19 Sep - 23 Sep	Ryanair
08 Sep - 11 Sep	Vueling Airlines
06 Sep - 10 Sep	Ryanair
30 Sep - 15 Oct	Vueling Airlines
30 Sep - 11 Oct	Vueling Airlines
30 Sep - 14 Oct	Vueling Airlines
16 Sep - 29 Sep	Vueling Airlines
03 Sep - 08 Sep	Ryanair
30 Sep - 09 Oct	Vueling Airlines
23 Sep - 11 Oct	Vueling Airlines
30 Sep - 21 Oct	Vueling Airlines
16 Sep - 04 Oct	Vueling Airlines
23 Sep - 09 Oct	Vueling Airlines
18 Sep - 04 Oct	Vueling Airlines

Also check the deals for one-way flights from Santiago to Prague in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Santiago to Prague in September from 153€

Return flights