AirHint found the following cheapest return flights from Santiago (SCL) to Mexico City (MEX) in September 2025 (see full year).

Return flights

28 Sep - 02 Oct	Copa
24 Sep - 05 Oct	Copa
24 Sep - 01 Oct	Copa
25 Sep - 01 Oct	Copa
23 Sep - 07 Oct	Copa
24 Sep - 06 Oct	Copa
26 Sep - 19 Oct	Copa
23 Sep - 03 Oct	Copa
19 Sep - 02 Oct	Copa
22 Sep - 29 Sep	Copa
26 Sep - 19 Oct	LATAM Airlines Group	direct
22 Sep - 25 Sep	Copa
22 Sep - 26 Sep	Copa
21 Sep - 26 Sep	Sky Airline
22 Sep - 29 Sep	LATAM Airlines Group	direct
30 Sep - 30 Sep	Copa
22 Sep - 25 Sep	LATAM Airlines Group	direct
22 Sep - 26 Sep	LATAM Airlines Group	direct
21 Sep - 26 Sep	LATAM Airlines Group	direct

Also check the deals for one-way flights from Santiago to Mexico City in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Santiago to Mexico City in September from 412€

Return flights