AirHint found the following cheapest return flights from Santiago (SCL) to Mexico City (MEX) in October 2025 (see full year).

Return flights

02 Oct - 07 Oct	Avianca
08 Oct - 24 Oct	Avianca
16 Oct - 25 Oct	Avianca
10 Oct - 19 Oct	Avianca
15 Oct - 22 Oct	Avianca
07 Oct - 17 Oct	Avianca
16 Oct - 23 Oct	Avianca
14 Oct - 19 Oct	Avianca
08 Oct - 15 Oct	Avianca
09 Oct - 17 Oct	Avianca
04 Oct - 30 Nov	Copa
06 Oct - 26 Nov	Avianca
29 Oct - 16 Nov	LATAM Airlines Group	direct
06 Oct - 26 Nov	LATAM Airlines Group	direct
28 Oct - 12 Nov	LATAM Airlines Group
23 Oct - 13 Nov	LATAM Airlines Group	direct
29 Oct - 04 Nov	LATAM Airlines Group
27 Oct - 06 Nov	LATAM Airlines Group
29 Oct - 03 Nov	LATAM Airlines Group
28 Oct - 09 Nov	LATAM Airlines Group

Also check the deals for one-way flights from Santiago to Mexico City in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Santiago to Mexico City in October from 408€

Return flights