AirHint found the following cheapest return flights from San Diego (SAN) to Panama City (PTY) in October 2025 (see full year).

Return flights

26 Oct - 31 Oct	Copa	direct
27 Oct - 31 Oct	Copa	direct
17 Oct - 22 Oct	Copa	direct
29 Oct - 02 Nov	Copa	direct
29 Oct - 03 Nov	Copa	direct
31 Oct - 05 Nov	Copa	direct
29 Oct - 05 Nov	Copa	direct
27 Oct - 01 Nov	Frontier Airlines
25 Oct - 30 Oct	Frontier Airlines
30 Oct - 04 Nov	Frontier Airlines
30 Oct - 03 Nov	Frontier Airlines
31 Oct - 04 Nov	Frontier Airlines
28 Oct - 02 Nov	Alaska Airlines
28 Oct - 01 Nov	Alaska Airlines
05 Oct - 14 Oct	Copa

Also check the deals for one-way flights from San Diego to Panama City in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from San Diego to Panama City in October from 433€

Return flights