AirHint found the following cheapest return flights from Rome (ROM) to Santiago (SCL) in September 2025 (see full year).

Return flights

01 Sep - 07 Sep	Delta
26 Sep - 17 Oct	Delta
12 Sep - 27 Sep	Delta
10 Sep - 24 Sep	Delta
14 Sep - 07 Oct	Delta
15 Sep - 22 Sep	Delta
18 Sep - 08 Oct	Delta
12 Sep - 18 Sep	Delta
19 Sep - 09 Oct	Delta
04 Sep - 18 Sep	Delta
05 Sep - 11 Sep	Norse Atlantic Airways
01 Sep - 11 Sep	KLM

Also check the deals for one-way flights from Rome to Santiago in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Rome to Santiago in September from 723€

Return flights