AirHint found the following cheapest return flights from Rome (ROM) to Santiago (SCL) in September 2025 (see full year).

Return flights

15 Sep - 28 Sep	Delta
07 Sep - 21 Sep	Delta
09 Sep - 16 Sep	Delta
17 Sep - 01 Oct	Delta
08 Sep - 06 Oct	Delta
23 Sep - 01 Oct	Delta
08 Sep - 07 Oct	Delta
25 Sep - 07 Oct	Delta
08 Sep - 10 Oct	Delta
11 Sep - 25 Sep	Air France
08 Sep - 08 Oct	Delta
25 Sep - 18 Oct	Delta
25 Sep - 08 Oct	Delta
12 Sep - 28 Sep	Transavia France
13 Sep - 26 Sep	Transavia France
24 Sep - 07 Oct	Delta
12 Sep - 21 Sep	Transavia France
08 Sep - 15 Sep	Delta
19 Sep - 23 Sep	Delta
11 Sep - 17 Sep	Delta

Also check the deals for one-way flights from Rome to Santiago in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

Book a cheap hotel in Santiago

Cheap car rent in Santiago

Cheapest return flights from Rome to Santiago in September from 715€

Return flights