AirHint found the following cheapest return flights from Rome (ROM) to Santiago (SCL) in December 2025 (see full year).

Return flights

03 Dec - 09 Dec	Delta
24 Dec - 15 Jan	Delta
10 Dec - 15 Jan	Delta
29 Dec - 14 Jan	Delta
07 Dec - 14 Dec	Delta
09 Dec - 13 Jan	Delta
01 Dec - 26 Jan	Delta
13 Dec - 22 Jan	Norse Atlantic Airways
02 Dec - 06 Dec	Ryanair
01 Dec - 29 Dec	Delta
13 Dec - 12 Jan	Norse Atlantic Airways
31 Dec - 17 Jan	Turkish Airlines
14 Dec - 15 Jan	Norse Atlantic Airways
30 Dec - 13 Jan	Turkish Airlines
09 Dec - 31 Dec	Wizz Air Malta
22 Dec - 30 Dec	Delta
20 Dec - 31 Dec	Wizz Air Malta

Also check the deals for one-way flights from Rome to Santiago in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Rome to Santiago in December from 716€

Return flights