AirHint found the following cheapest return flights from Rome (ROM) to Santiago (SCL) in December 2025 (see full year).

Return flights

03 Dec - 13 Dec	Iberia
07 Dec - 22 Jan	Delta
05 Dec - 14 Dec	Iberia
04 Dec - 19 Dec	Iberia
04 Dec - 13 Dec	Iberia
09 Dec - 18 Dec	Iberia
30 Dec - 13 Jan	Air Canada
31 Dec - 18 Jan	Iberia
24 Dec - 27 Dec	Delta
24 Dec - 28 Dec	Delta
07 Dec - 16 Jan	Iberia
26 Dec - 14 Jan	Iberia
29 Dec - 14 Jan	Iberia
08 Dec - 16 Jan	Iberia
31 Dec - 17 Jan	Iberia
07 Dec - 17 Jan	Iberia
27 Dec - 15 Jan	Delta
06 Dec - 20 Dec	Ryanair
21 Dec - 30 Dec	Iberia
09 Dec - 31 Dec	Air France

Also check the deals for one-way flights from Rome to Santiago in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Rome to Santiago in December from 675€

Return flights