AirHint found the following cheapest return flights from Rome (ROM) to Santiago (SCL) in December 2025 (see full year).

Return flights

16 Dec - 20 Jan	Air Canada
28 Dec - 16 Jan	Delta
29 Dec - 16 Jan	Delta
27 Dec - 16 Jan	Delta
26 Dec - 13 Jan	Iberia
26 Dec - 10 Jan	Iberia For Level
29 Dec - 05 Jan	Iberia For Level
25 Dec - 05 Jan	Iberia
21 Dec - 10 Jan	Iberia For Level
22 Dec - 05 Jan	Iberia For Level
18 Dec - 28 Dec	Iberia

Also check the deals for one-way flights from Rome to Santiago in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Rome to Santiago in December from 707€

Return flights