AirHint found the following cheapest return flights from Rome (ROM) to Santiago (SCL) in October 2025 (see full year).

Return flights

08 Oct - 21 Oct	Delta
07 Oct - 20 Oct	Delta
09 Oct - 24 Oct	Delta
23 Oct - 13 Nov	Delta
23 Oct - 08 Nov	Delta
21 Oct - 04 Nov	Wizz Air Malta
24 Oct - 15 Nov	Delta
09 Oct - 17 Oct	Delta
21 Oct - 18 Nov	Condor
26 Oct - 05 Nov	Delta
15 Oct - 12 Nov	Ryanair
29 Oct - 09 Nov	Delta
25 Oct - 09 Nov	TAP
16 Oct - 15 Nov	Delta
01 Oct - 04 Oct	Ryanair
06 Oct - 11 Oct	Delta
04 Oct - 18 Oct	TAP
03 Oct - 25 Oct	Wizz Air Malta
17 Oct - 24 Oct	Turkish Airlines
08 Oct - 09 Oct	Wizz Air Malta

Also check the deals for one-way flights from Rome to Santiago in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Rome to Santiago in October from 733€

Return flights