AirHint found the following cheapest return flights from Rome (ROM) to Sao Paulo (GRU) in September 2025 (see full year).

Return flights

29 Sep - 13 Oct	TAP
17 Sep - 23 Sep	TAP
18 Sep - 31 Oct	TAP
19 Sep - 08 Oct	TAP
18 Sep - 23 Sep	TAP
20 Sep - 20 Oct	TAP
23 Sep - 07 Oct	TAP
14 Sep - 06 Oct	TAP
12 Sep - 26 Sep	Delta
19 Sep - 26 Sep	Delta
12 Sep - 29 Sep	Delta
17 Sep - 28 Sep	Delta
17 Sep - 29 Sep	Delta
12 Sep - 28 Sep	Delta
16 Sep - 23 Sep	Delta
15 Sep - 28 Sep	Delta
22 Sep - 31 Oct	Delta
18 Sep - 31 Oct	LATAM Airlines Group	direct
29 Sep - 30 Oct	Ryanair
29 Sep - 12 Oct	TAP

Also check the deals for one-way flights from Rome to Sao Paulo in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

Book a cheap hotel in Sao Paulo

Cheap car rent in Sao Paulo

Cheapest return flights from Rome to Sao Paulo in September from 589€

Return flights