Cheapest return flights from Panama City to Santa Cruz in September from 478€

AirHint found the following cheapest return flights from Panama City (PTY) to Santa Cruz (VVI) in September 2025 (see full year).

Return flights

20 Sep - 27 Sep Avianca
25 Sep - 04 Oct Avianca
20 Sep - 27 Sep Copa direct
25 Sep - 04 Oct Copa direct

Also check the deals for one-way flights from Panama City to Santa Cruz in September.

Skyscanner

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

Book a cheap hotel in Santa Cruz

Cheap car rent in Santa Cruz

Feel free to contact us with any feedback or request another flight research.