AirHint found the following cheapest return flights from Panama City (PTY) to Quito (UIO) in December 2025 (see full year).

Return flights

20 Dec - 22 Dec	Avianca
10 Dec - 17 Dec	Avianca
12 Dec - 12 Jan	Avianca
18 Dec - 18 Jan	Avianca
15 Dec - 31 Dec	Avianca
12 Dec - 31 Dec	Avianca
26 Dec - 05 Jan	Copa	direct
30 Dec - 06 Jan	Copa	direct
08 Dec - 12 Dec	Avianca
31 Dec - 04 Jan	Copa	direct
19 Dec - 21 Dec	Avianca
11 Dec - 15 Dec	Avianca
07 Dec - 15 Dec	Avianca
15 Dec - 31 Dec	Copa	direct
12 Dec - 31 Dec	Copa	direct
12 Dec - 12 Jan	Copa	direct
18 Dec - 18 Jan	Copa	direct

Also check the deals for one-way flights from Panama City to Quito in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Panama City to Quito in December from 322€

Return flights