AirHint found the following cheapest return flights from Panama City (PTY) to Santo Domingo (SDQ) in September 2025 (see full year).

Return flights

25 Sep - 30 Sep	Avianca
04 Sep - 11 Sep	Avianca
15 Sep - 30 Sep	Avianca
01 Sep - 09 Sep	Avianca
16 Sep - 22 Sep	Copa	direct
04 Sep - 11 Sep	Copa	direct
15 Sep - 30 Sep	Copa	direct
01 Sep - 09 Sep	Copa	direct
25 Sep - 30 Sep	Copa	direct
26 Sep - 13 Oct	Copa	direct

Also check the deals for one-way flights from Panama City to Santo Domingo in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Panama City to Santo Domingo in September from 267€

Return flights