AirHint found the following cheapest return flights from Panama City (PTY) to Santo Domingo (SDQ) in October 2025 (see full year).

Return flights

17 Oct - 20 Oct	Copa	direct
03 Oct - 06 Oct	Copa	direct
03 Oct - 13 Oct	Copa	direct
06 Oct - 13 Oct	Copa	direct
12 Oct - 19 Oct	Copa	direct
13 Oct - 20 Oct	Copa	direct
16 Oct - 23 Oct	Copa	direct
02 Oct - 05 Oct	Copa	direct
10 Oct - 12 Oct	Copa	direct
07 Oct - 10 Oct	Copa	direct
03 Oct - 10 Nov	Copa	direct
26 Oct - 26 Nov	Copa	direct
31 Oct - 05 Nov	Copa	direct

Also check the deals for one-way flights from Panama City to Santo Domingo in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Panama City to Santo Domingo in October from 383€

Return flights