AirHint found the following cheapest return flights from Panama City (PTY) to Mexico City (MEX) in September 2025 (see full year).

Return flights

17 Sep - 24 Sep	Copa	direct
19 Sep - 26 Sep	Copa	direct
18 Sep - 25 Sep	Copa	direct
29 Sep - 13 Oct	Copa	direct
26 Sep - 05 Oct	Copa	direct
19 Sep - 28 Sep	Copa	direct
29 Sep - 02 Oct	Copa	direct
26 Sep - 28 Sep	Avianca
18 Sep - 28 Sep	Avianca
22 Sep - 06 Oct	Avianca
22 Sep - 26 Sep	Avianca
22 Sep - 13 Oct	Avianca
22 Sep - 06 Oct	Copa	direct
22 Sep - 13 Oct	Copa	direct
26 Sep - 28 Sep	Copa	direct
18 Sep - 28 Sep	Copa	direct
22 Sep - 26 Sep	Copa	direct

Also check the deals for one-way flights from Panama City to Mexico City in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Panama City to Mexico City in September from 292€

Return flights