AirHint found the following cheapest return flights from Panama City (PTY) to Mexico City (MEX) in September 2025 (see full year).

Return flights

30 Sep - 08 Oct	Avianca
03 Sep - 09 Sep	Avianca
18 Sep - 21 Sep	Avianca
17 Sep - 24 Sep	Avianca
30 Sep - 08 Oct	Aeromexico	direct
21 Sep - 27 Sep	Avianca
16 Sep - 29 Sep	Avianca
19 Sep - 24 Sep	Avianca
09 Sep - 16 Sep	Copa	direct
12 Sep - 20 Sep	Avianca
21 Sep - 27 Sep	Copa	direct
03 Sep - 09 Sep	Copa	direct

Also check the deals for one-way flights from Panama City to Mexico City in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Panama City to Mexico City in September from 268€

Return flights