AirHint found the following cheapest return flights from Panama City (PTY) to Mexico City (MEX) in October 2025 (see full year).

Return flights

26 Oct - 12 Nov	Avianca
22 Oct - 29 Oct	Copa	direct
20 Oct - 26 Oct	Copa	direct
18 Oct - 20 Oct	Avianca
27 Oct - 07 Nov	Avianca
21 Oct - 28 Oct	Avianca
31 Oct - 10 Nov	Avianca
29 Oct - 10 Nov	Avianca
31 Oct - 09 Nov	Avianca
23 Oct - 25 Oct	Avianca
23 Oct - 27 Oct	Avianca
31 Oct - 06 Nov	Avianca
28 Oct - 11 Nov	Avianca
31 Oct - 08 Nov	Avianca
24 Oct - 11 Nov	Avianca
31 Oct - 05 Nov	Avianca
18 Oct - 19 Oct	Avianca
23 Oct - 25 Oct	Copa	direct
24 Oct - 27 Oct	Copa	direct
21 Oct - 28 Oct	Copa	direct

Also check the deals for one-way flights from Panama City to Mexico City in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Panama City to Mexico City in October from 266€

Return flights