AirHint found the following cheapest return flights from Panama City (PTY) to Mexico City (MEX) in October 2025 (see full year).

Return flights

01 Oct - 15 Oct	Copa	direct
10 Oct - 21 Oct	Copa	direct
01 Oct - 11 Oct	Copa	direct
10 Oct - 15 Oct	Copa	direct
03 Oct - 05 Oct	Copa	direct
10 Oct - 13 Oct	Copa	direct
09 Oct - 13 Oct	Copa	direct
28 Oct - 02 Nov	Aeromexico	direct
17 Oct - 10 Nov	Aeromexico	direct
16 Oct - 26 Oct	Aeromexico	direct
12 Oct - 19 Oct	Copa
27 Oct - 23 Nov	Avianca
11 Oct - 13 Oct	Copa	direct
31 Oct - 10 Nov	Avianca
31 Oct - 08 Nov	Avianca
31 Oct - 09 Nov	Avianca
27 Oct - 07 Nov	Avianca
31 Oct - 06 Nov	Avianca
30 Oct - 30 Nov	Avianca
30 Oct - 30 Nov	Copa	direct

Also check the deals for one-way flights from Panama City to Mexico City in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Panama City to Mexico City in October from 292€

Return flights