AirHint found the following cheapest return flights from Panama City (PTY) to Rio Negro (MDE) in September 2025 (see full year).

Return flights

23 Sep - 30 Sep	Wingo	direct
27 Sep - 01 Oct	Wingo	direct
20 Sep - 23 Sep	Wingo	direct
22 Sep - 29 Sep	Wingo	direct
21 Sep - 23 Sep	Wingo	direct
23 Sep - 27 Sep	Wingo	direct
19 Sep - 23 Sep	Wingo	direct
22 Sep - 26 Sep	Wingo	direct
20 Sep - 20 Sep	Wingo
21 Sep - 28 Sep	Wingo
26 Sep - 30 Sep	Copa	direct
26 Sep - 30 Oct	Avianca

Also check the deals for one-way flights from Panama City to Rio Negro in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Panama City to Rio Negro in September from 152€

Return flights