AirHint found the following cheapest return flights from Panama City (PTY) to Rio Negro (MDE) in December 2025 (see full year).

Return flights

17 Dec - 17 Jan	Wingo	direct
11 Dec - 16 Dec	Wingo	direct
09 Dec - 09 Jan	Wingo	direct
25 Dec - 09 Jan	Wingo	direct
02 Dec - 05 Dec	Copa	direct
02 Dec - 04 Dec	Copa	direct
01 Dec - 07 Dec	Copa	direct
02 Dec - 13 Dec	Copa	direct
12 Dec - 18 Dec	Copa	direct
08 Dec - 12 Dec	Copa	direct
12 Dec - 14 Dec	Copa	direct
20 Dec - 22 Dec	Avianca
16 Dec - 24 Dec	Avianca
17 Dec - 13 Jan	Avianca
17 Dec - 06 Jan	Avianca
28 Dec - 04 Jan	Avianca
17 Dec - 13 Jan	Copa	direct
19 Dec - 03 Jan	Avianca
26 Dec - 03 Jan	Avianca
09 Dec - 13 Jan	Avianca

Also check the deals for one-way flights from Panama City to Rio Negro in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Panama City to Rio Negro in December from 204€

Return flights