AirHint found the following cheapest return flights from Panama City (PTY) to Rio Negro (MDE) in December 2025 (see full year).

Return flights

27 Dec - 29 Dec	Wingo	direct
25 Dec - 28 Dec	Wingo	direct
25 Dec - 29 Dec	Wingo	direct
27 Dec - 30 Dec	Wingo	direct
21 Dec - 27 Dec	Wingo	direct
26 Dec - 29 Dec	Wingo	direct
26 Dec - 30 Dec	Wingo	direct
24 Dec - 26 Dec	Wingo
21 Dec - 25 Dec	Wingo	direct
21 Dec - 26 Dec	Wingo	direct
29 Dec - 12 Jan	Copa	direct
27 Dec - 09 Jan	Copa	direct
27 Dec - 03 Jan	Copa	direct
28 Dec - 05 Jan	Avianca
30 Dec - 05 Jan	Avianca
25 Dec - 10 Jan	Avianca
30 Dec - 06 Jan	Copa	direct
23 Dec - 29 Jan	Copa	direct
25 Dec - 10 Jan	Copa	direct
20 Dec - 19 Jan	Copa	direct

Also check the deals for one-way flights from Panama City to Rio Negro in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Panama City to Rio Negro in December from 170€

Return flights