AirHint found the following cheapest return flights from Panama City (PTY) to Rio Negro (MDE) in December 2025 (see full year).

Return flights

03 Dec - 07 Dec	Wingo	direct
30 Dec - 09 Jan	Wingo	direct
28 Dec - 18 Jan	Wingo	direct
27 Dec - 09 Jan	Wingo	direct
21 Dec - 10 Jan	Wingo	direct
19 Dec - 30 Dec	Wingo	direct
25 Dec - 01 Jan	Wingo	direct
22 Dec - 26 Dec	Wingo	direct
22 Dec - 02 Jan	Wingo	direct
12 Dec - 14 Dec	Copa	direct
23 Dec - 26 Dec	Avianca
20 Dec - 28 Dec	Avianca
09 Dec - 12 Dec	Avianca
12 Dec - 18 Dec	Avianca
09 Dec - 12 Dec	Copa	direct
12 Dec - 18 Dec	Copa	direct
23 Dec - 14 Jan	Avianca
28 Dec - 20 Jan	Copa	direct
23 Dec - 14 Jan	Copa	direct

Also check the deals for one-way flights from Panama City to Rio Negro in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Panama City to Rio Negro in December from 185€

Return flights