AirHint found the following cheapest return flights from Panama City (PTY) to Rio Negro (MDE) in October 2025 (see full year).

Return flights

09 Oct - 15 Oct	Wingo	direct
21 Oct - 25 Oct	Wingo	direct
10 Oct - 12 Oct	Wingo	direct
10 Oct - 15 Oct	Wingo	direct
11 Oct - 12 Oct	Wingo	direct
04 Oct - 11 Oct	Wingo	direct
16 Oct - 19 Oct	Avianca	direct
11 Oct - 23 Oct	Avianca	direct
20 Oct - 25 Oct	Avianca	direct
02 Oct - 06 Oct	Copa	direct
31 Oct - 04 Nov	Avianca	direct
31 Oct - 02 Nov	Avianca	direct
31 Oct - 06 Nov	Avianca	direct
31 Oct - 05 Nov	Avianca
31 Oct - 05 Nov	Copa	direct

Also check the deals for one-way flights from Panama City to Rio Negro in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Panama City to Rio Negro in October from 129€

Return flights