AirHint found the following cheapest return flights from Panama City (PTY) to Rio Negro (MDE) in October 2025 (see full year).

Return flights

10 Oct - 15 Oct	Wingo	direct
08 Oct - 14 Oct	Wingo	direct
24 Oct - 28 Oct	Wingo	direct
24 Oct - 29 Oct	Wingo	direct
05 Oct - 22 Oct	Wingo	direct
22 Oct - 26 Oct	Wingo	direct
06 Oct - 09 Oct	Wingo	direct
22 Oct - 28 Oct	Wingo	direct
15 Oct - 22 Oct	Wingo	direct
28 Oct - 02 Nov	Wingo	direct
03 Oct - 07 Oct	Wingo	direct
31 Oct - 04 Nov	Avianca
30 Oct - 05 Nov	Avianca
30 Oct - 06 Nov	Avianca
31 Oct - 05 Nov	Avianca
31 Oct - 03 Nov	Avianca
30 Oct - 06 Nov	Copa	direct
31 Oct - 07 Nov	Avianca
31 Oct - 09 Nov	Wingo	direct
31 Oct - 03 Nov	Wingo	direct

Also check the deals for one-way flights from Panama City to Rio Negro in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Panama City to Rio Negro in October from 151€

Return flights