AirHint found the following cheapest return flights from Panama City (PTY) to Rio Negro (MDE) in October 2025 (see full year).

Return flights

10 Oct - 15 Oct	Wingo	direct
21 Oct - 24 Oct	Wingo	direct
10 Oct - 13 Oct	Wingo	direct
07 Oct - 10 Oct	Copa	direct
02 Oct - 05 Oct	Avianca	direct
16 Oct - 19 Oct	Copa	direct
31 Oct - 10 Nov	Avianca	direct
18 Oct - 02 Nov	Copa	direct
31 Oct - 04 Nov	Avianca	direct
31 Oct - 05 Nov	Copa	direct

Also check the deals for one-way flights from Panama City to Rio Negro in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Panama City to Rio Negro in October from 145€

Return flights