AirHint found the following cheapest return flights from Panama City (PTY) to Madrid (MAD) in November 2025 (see full year).

Return flights

24 Nov - 30 Nov	Turkish Airlines
15 Nov - 18 Nov	Turkish Airlines
12 Nov - 30 Nov	Turkish Airlines
21 Nov - 28 Nov	Air Europa	direct
13 Nov - 28 Nov	Air Europa	direct
12 Nov - 24 Nov	Iberia	direct
17 Nov - 28 Nov	Air Europa	direct
10 Nov - 24 Nov	Iberia	direct
10 Nov - 25 Nov	Turkish Airlines
15 Nov - 22 Nov	Turkish Airlines
20 Nov - 03 Dec	Air France
30 Nov - 03 Dec	Air France
20 Nov - 02 Dec	Air France
17 Nov - 01 Dec	Iberia	direct
27 Nov - 01 Dec	Air France
19 Nov - 01 Dec	Air France
19 Nov - 12 Dec	United
21 Nov - 01 Dec	Air France
27 Nov - 04 Dec	Air France
10 Nov - 10 Dec	Iberia

Also check the deals for one-way flights from Panama City to Madrid in November.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Panama City to Madrid in November from 612€

Return flights