AirHint found the following cheapest return flights from Panama City (PTY) to Madrid (MAD) in November 2025 (see full year).

Return flights

05 Nov - 14 Nov	KLM
11 Nov - 25 Nov	Avianca
05 Nov - 18 Nov	Avianca
14 Nov - 19 Nov	Avianca
14 Nov - 17 Nov	Avianca
01 Nov - 08 Nov	Avianca
01 Nov - 09 Nov	Avianca
01 Nov - 17 Nov	Avianca
01 Nov - 06 Nov	Avianca
14 Nov - 25 Nov	Avianca
17 Nov - 07 Dec	Turkish Airlines
18 Nov - 06 Dec	Air France
21 Nov - 01 Dec	Turkish Airlines
21 Nov - 01 Dec	Air Europa	direct
18 Nov - 06 Dec	Air Europa	direct

Also check the deals for one-way flights from Panama City to Madrid in November.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Panama City to Madrid in November from 610€

Return flights