Cheapest return flights from Panama City to Madrid in October from 662€

Best time to book flights for Panama City (PTY) to Madrid (MAD) flights at AirHint

AirHint found the following cheapest return flights from Panama City (PTY) to Madrid (MAD) in October 2025 (see full year).

Return flights

15 Oct - 27 Oct Air Europa direct
27 Oct - 12 Nov Iberia direct
07 Oct - 14 Oct Air Europa direct
05 Oct - 11 Oct Air France
05 Oct - 11 Oct Air Europa direct
02 Oct - 16 Oct Iberia direct
05 Oct - 12 Oct Air Europa direct
29 Oct - 14 Nov Air Europa direct
10 Oct - 25 Oct Air Europa direct
12 Oct - 19 Oct Air Europa direct
06 Oct - 17 Oct Air France
05 Oct - 16 Oct KLM
26 Oct - 02 Nov Air Europa direct

Also check the deals for one-way flights from Panama City to Madrid in October.

Skyscanner

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

Book a cheap hotel in Madrid

Cheap car rent in Madrid