AirHint found the following cheapest return flights from Panama City (PTY) to Madrid (MAD) in October 2025 (see full year).

Return flights

12 Oct - 22 Oct	Avianca
27 Oct - 17 Nov	Avianca
20 Oct - 27 Oct	Avianca
07 Oct - 27 Oct	Air France
28 Oct - 06 Nov	Air Europa	direct
28 Oct - 11 Nov	Air Europa	direct
13 Oct - 29 Oct	Avianca
08 Oct - 21 Oct	Avianca
20 Oct - 24 Oct	Avianca
11 Oct - 26 Oct	Avianca
08 Oct - 29 Oct	Avianca
26 Oct - 29 Oct	Avianca
31 Oct - 16 Nov	Avianca
24 Oct - 09 Nov	Avianca
28 Oct - 09 Nov	Avianca
23 Oct - 04 Nov	Avianca
23 Oct - 08 Nov	Avianca
16 Oct - 08 Nov	Avianca
20 Oct - 03 Nov	Iberia	direct
23 Oct - 27 Oct	Air France

Also check the deals for one-way flights from Panama City to Madrid in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Panama City to Madrid in October from 611€

Return flights