AirHint found the following cheapest return flights from Panama City (PTY) to Madrid (MAD) in October 2025 (see full year).

Return flights

23 Oct - 24 Nov	Iberia	direct
23 Oct - 30 Oct	Air France
20 Oct - 20 Nov	Air France
20 Oct - 31 Oct	KLM
20 Oct - 11 Nov	Iberia
19 Oct - 30 Oct	Air France
25 Oct - 03 Nov	Iberia	direct
30 Oct - 09 Nov	Avianca
30 Oct - 11 Nov	Avianca
23 Oct - 01 Nov	Iberia	direct
19 Oct - 26 Oct	Avianca
24 Oct - 30 Oct	Avianca
30 Oct - 08 Nov	Avianca
29 Oct - 10 Nov	Avianca
29 Oct - 11 Nov	Avianca
21 Oct - 29 Oct	Avianca
19 Oct - 20 Oct	Avianca
22 Oct - 29 Oct	Avianca
25 Oct - 29 Oct	Avianca
19 Oct - 28 Oct	Avianca

Also check the deals for one-way flights from Panama City to Madrid in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Panama City to Madrid in October from 640€

Return flights