AirHint found the following cheapest return flights from Panama City (PTY) to Madrid (MAD) in October 2025 (see full year).

Return flights

30 Oct - 10 Nov	Avianca
21 Oct - 31 Oct	KLM
31 Oct - 17 Nov	Avianca
12 Oct - 26 Oct	Air France
24 Oct - 11 Nov	Avianca
31 Oct - 11 Nov	Avianca
01 Oct - 01 Nov	Air France
13 Oct - 29 Oct	Iberia	direct
13 Oct - 25 Oct	KLM
22 Oct - 07 Nov	Turkish Airlines
09 Oct - 23 Oct	Iberia	direct
17 Oct - 24 Oct	Air Europa	direct
16 Oct - 23 Oct	Iberia	direct
31 Oct - 22 Nov	Avianca
23 Oct - 30 Oct	Turkish Airlines
01 Oct - 15 Oct	Air France
12 Oct - 22 Oct	Air Europa	direct
31 Oct - 08 Nov	Avianca
31 Oct - 09 Nov	Avianca
20 Oct - 03 Nov	Avianca

Also check the deals for one-way flights from Panama City to Madrid in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Panama City to Madrid in October from 609€

Return flights