Cheapest return flights from Panama City to Madrid in October from 725€

Best time to book flights for Panama City (PTY) to Madrid (MAD) flights at AirHint

AirHint found the following cheapest return flights from Panama City (PTY) to Madrid (MAD) in October 2025 (see full year).

Return flights

17 Oct - 24 Oct Air Europa direct
24 Oct - 05 Nov Air Europa direct
12 Oct - 29 Oct Air France
03 Oct - 11 Oct Air Europa direct
01 Oct - 08 Oct Air Europa direct
13 Oct - 04 Nov Air Europa direct
01 Oct - 20 Oct Air Europa direct
13 Oct - 29 Oct Air France
07 Oct - 15 Oct United

Also check the deals for one-way flights from Panama City to Madrid in October.

Skyscanner

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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