Cheapest one-way flights from Panama City to Madrid in October from 533€

Best time to book flights for Panama City (PTY) to Madrid (MAD) flights at AirHint

AirHint found the following cheapest one-way flights from Panama City (PTY) to Madrid (MAD) in October 2025 (see full year).

One-Way flights

11 Oct Avianca
11 Oct Air Europa direct

Also check the deals for return flights from Panama City to Madrid in October.

Skyscanner

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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