AirHint found the following cheapest return flights from Panama City (PTY) to Istanbul (IST) in September 2025 (see full year).

Return flights

26 Sep - 12 Oct	Air Europa
22 Sep - 26 Sep	Copa
05 Sep - 20 Sep	Copa
08 Sep - 15 Sep	Copa
18 Sep - 24 Sep	Copa
22 Sep - 27 Sep	Copa
23 Sep - 28 Sep	Copa
17 Sep - 23 Sep	Copa
21 Sep - 28 Sep	Copa
18 Sep - 23 Oct	Air Europa
20 Sep - 27 Sep	Copa
13 Sep - 20 Sep	Copa
10 Sep - 08 Oct	KLM
17 Sep - 21 Oct	Turkish Airlines
26 Sep - 12 Oct	Turkish Airlines	direct

Also check the deals for one-way flights from Panama City to Istanbul in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Panama City to Istanbul in September from 840€

Return flights