AirHint found the following cheapest return flights from Panama City (PTY) to Istanbul (IST) in September 2025 (see full year).

Return flights

21 Sep - 28 Sep	Avianca
20 Sep - 27 Sep	Avianca
22 Sep - 09 Oct	Avianca
19 Sep - 21 Sep	Avianca
25 Sep - 10 Oct	Avianca
23 Sep - 10 Oct	Avianca
20 Sep - 05 Oct	Avianca
22 Sep - 22 Oct	Avianca
24 Sep - 04 Oct	Avianca
24 Sep - 05 Oct	Avianca
25 Sep - 05 Oct	Copa
24 Sep - 05 Oct	Copa	direct
17 Sep - 24 Sep	Copa
16 Sep - 22 Sep	KLM
19 Sep - 21 Sep	Copa	direct
19 Sep - 26 Sep	Copa	direct
21 Sep - 28 Sep	Copa	direct
23 Sep - 10 Oct	Turkish Airlines	direct

Also check the deals for one-way flights from Panama City to Istanbul in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Panama City to Istanbul in September from 827€

Return flights