AirHint found the following cheapest return flights from Panama City (PTY) to Guatemala City (GUA) in September 2025 (see full year).

Return flights

02 Sep - 28 Oct	Avianca
12 Sep - 15 Sep	Copa
15 Sep - 21 Sep	Copa	direct
21 Sep - 22 Sep	Copa
02 Sep - 28 Oct	Copa	direct
29 Sep - 06 Oct	Copa	direct
26 Sep - 10 Oct	Avianca
02 Sep - 11 Sep	Avianca
23 Sep - 06 Oct	Avianca
12 Sep - 12 Sep	Avianca
11 Sep - 11 Sep	Avianca
02 Sep - 11 Sep	Copa	direct
23 Sep - 06 Oct	Copa	direct
11 Sep - 11 Sep	Copa	direct
12 Sep - 12 Sep	Copa	direct
10 Sep - 10 Sep	Copa	direct

Also check the deals for one-way flights from Panama City to Guatemala City in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Panama City to Guatemala City in September from 222€

Return flights