AirHint found the following cheapest return flights from Pisa (PSA) to Istanbul (IST) in December 2025 (see full year).

Return flights

04 Dec - 08 Dec	Wizz Air Malta
05 Dec - 08 Dec	Wizz Air Malta
06 Dec - 09 Dec	Wizz Air Malta
08 Dec - 13 Dec	easyJet
19 Dec - 22 Dec	Ryanair
27 Dec - 30 Dec	Ryanair
24 Dec - 30 Dec	Ryanair
26 Dec - 06 Jan	Wizz Air Malta
24 Dec - 28 Dec	Ryanair
28 Dec - 01 Jan	KLM
26 Dec - 02 Jan	Wizz Air Malta
29 Dec - 02 Jan	Ryanair

Also check the deals for one-way flights from Pisa to Istanbul in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Pisa to Istanbul in December from 148€

Return flights