AirHint found the following cheapest return flights from Prague (PRG) to Panama City (PTY) in November 2025 (see full year).

Return flights

03 Nov - 17 Nov	Condor
06 Nov - 13 Nov	Condor
06 Nov - 10 Nov	Condor
10 Nov - 24 Nov	Condor
27 Nov - 11 Dec	Condor
17 Nov - 24 Nov	Condor
17 Nov - 27 Nov	Condor
20 Nov - 06 Dec	Wizz Air Malta
21 Nov - 06 Dec	Wizz Air Malta
06 Nov - 11 Nov	easyJet
05 Nov - 20 Nov	Lufthansa
12 Nov - 20 Nov	Lufthansa
05 Nov - 10 Nov	Lufthansa
20 Nov - 03 Dec	Condor

Also check the deals for one-way flights from Prague to Panama City in November.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Prague to Panama City in November from 481€

Return flights