AirHint found the following cheapest return flights from Prague (PRG) to Istanbul (IST) in October 2025 (see full year).

Return flights

09 Oct - 13 Oct	Wizz Air UK
04 Oct - 07 Oct	Wizz Air UK
02 Oct - 07 Oct	Wizz Air UK
09 Oct - 11 Oct	Wizz Air UK
11 Oct - 15 Oct	Wizz Air Malta
09 Oct - 16 Oct	Wizz Air UK
06 Oct - 08 Oct	Ryanair
10 Oct - 14 Oct	Wizz Air UK
10 Oct - 17 Oct	Pegasus Airlines
22 Oct - 24 Oct	Pegasus Airlines
24 Oct - 02 Nov	Pegasus Airlines	direct
28 Oct - 07 Nov	Fly One
28 Oct - 11 Nov	Fly One
28 Oct - 08 Nov	Fly One
28 Oct - 06 Nov	Fly One
28 Oct - 04 Nov	Fly One
28 Oct - 10 Nov	Fly One
28 Oct - 03 Nov	Fly One
28 Oct - 15 Nov	Fly One
28 Oct - 18 Nov	Fly One

Also check the deals for one-way flights from Prague to Istanbul in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Prague to Istanbul in October from 101€

Return flights