AirHint found the following cheapest return flights from Palermo (PMO) to Prague (PRG) in October 2025 (see full year).

Return flights

01 Oct - 04 Oct	easyJet
01 Oct - 07 Oct	easyJet
16 Oct - 20 Oct	easyJet
03 Oct - 07 Oct	easyJet
23 Oct - 26 Oct	easyJet
03 Oct - 06 Oct	easyJet
23 Oct - 27 Oct	Ryanair
13 Oct - 19 Oct	Aeroitalia
22 Oct - 26 Oct	Ryanair
27 Oct - 02 Nov	Ryanair
05 Oct - 12 Oct	Vueling Airlines

Also check the deals for one-way flights from Palermo to Prague in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

Book a cheap hotel in Prague

Cheap car rent in Prague

Cheapest return flights from Palermo to Prague in October from 108€

Return flights