AirHint found the following cheapest return flights from Palermo (PMO) to Istanbul (IST) in September 2025 (see full year).

Return flights

24 Sep - 01 Oct	Aeroitalia
23 Sep - 28 Sep	Ryanair
25 Sep - 29 Sep	Volotea
21 Sep - 28 Sep	Ryanair
22 Sep - 29 Sep	Aeroitalia
23 Sep - 26 Sep	Aeroitalia
15 Sep - 18 Sep	Ryanair
08 Sep - 18 Sep	Aeroitalia
08 Sep - 16 Sep	Aeroitalia
21 Sep - 27 Sep	Aeroitalia
22 Sep - 28 Sep	Ryanair
28 Sep - 01 Oct	Ryanair
18 Sep - 01 Oct	Aeroitalia
25 Sep - 01 Oct	Aeroitalia
27 Sep - 01 Oct	Aeroitalia
29 Sep - 05 Oct	easyJet
27 Sep - 04 Oct	Air Serbia
27 Sep - 30 Oct	Ryanair
18 Sep - 01 Oct	Turkish Airlines	direct
24 Sep - 01 Oct	Turkish Airlines	direct

Also check the deals for one-way flights from Palermo to Istanbul in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Palermo to Istanbul in September from 177€

Return flights