AirHint found the following cheapest return flights from Palermo (PMO) to Istanbul (IST) in September 2025 (see full year).

Return flights

23 Sep - 26 Sep	Ryanair
20 Sep - 24 Sep	Transavia France
16 Sep - 30 Sep	Volotea
13 Sep - 16 Sep	Ryanair
25 Sep - 29 Sep	Aeroitalia
30 Sep - 08 Oct	Ryanair
20 Sep - 23 Sep	Aeroitalia
24 Sep - 02 Oct	Aeroitalia
17 Sep - 24 Sep	Aeroitalia
30 Sep - 06 Oct	easyJet
19 Sep - 23 Sep	Volotea
10 Sep - 19 Sep	Ryanair
24 Sep - 28 Sep	Ryanair
30 Sep - 05 Oct	Ryanair
23 Sep - 01 Oct	Aeroitalia
27 Sep - 01 Oct	Ryanair
28 Sep - 06 Oct	Ryanair
29 Sep - 04 Oct	Ryanair
29 Sep - 05 Oct	Ryanair
29 Sep - 01 Oct	Ryanair

Also check the deals for one-way flights from Palermo to Istanbul in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

Book a cheap hotel in Istanbul

Cheap car rent in Istanbul

Cheapest return flights from Palermo to Istanbul in September from 188€

Return flights