AirHint found the following cheapest return flights from Palermo (PMO) to Istanbul (IST) in September 2025 (see full year).

Return flights

23 Sep - 30 Sep	easyJet
10 Sep - 14 Sep	Aegean Airlines
25 Sep - 30 Sep	easyJet
11 Sep - 17 Sep	Aeroitalia
21 Sep - 28 Sep	Aeroitalia
08 Sep - 14 Sep	Volotea
11 Sep - 14 Sep	Aeroitalia
26 Sep - 30 Sep	Aeroitalia
25 Sep - 03 Oct	easyJet
25 Sep - 02 Oct	easyJet
04 Sep - 10 Sep	Ryanair
02 Sep - 15 Sep	Volotea
24 Sep - 01 Oct	Ryanair
24 Sep - 02 Oct	Aeroitalia
27 Sep - 01 Oct	Transavia France
28 Sep - 05 Oct	easyJet
27 Sep - 02 Oct	Ryanair
24 Sep - 02 Oct	Turkish Airlines	direct
24 Sep - 01 Oct	Turkish Airlines	direct
25 Sep - 02 Oct	Turkish Airlines	direct

Also check the deals for one-way flights from Palermo to Istanbul in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Palermo to Istanbul in September from 184€

Return flights