AirHint found the following cheapest return flights from Palermo (PMO) to Istanbul (IST) in May 2026 (see full year).

Return flights

06 May - 11 May	Ryanair
12 May - 16 May	Ryanair
05 May - 08 May	Ryanair
25 May - 29 May	Ryanair
22 May - 29 May	easyJet
09 May - 16 May	Ryanair
08 May - 14 May	Ryanair
15 May - 22 May	Ryanair
07 May - 12 May	Ryanair
09 May - 12 May	Ryanair
28 May - 01 Jun	Volotea
28 May - 02 Jun	Volotea
30 May - 06 Jun	easyJet
29 May - 02 Jun	Volotea
27 May - 10 Jun	Vueling Airlines
30 May - 02 Jun	easyJet
27 May - 16 Jun	Vueling Airlines
16 May - 01 Jun	Vueling Airlines
27 May - 01 Jun	Vueling Airlines
19 May - 01 Jun	Vueling Airlines

Also check the deals for one-way flights from Palermo to Istanbul in May.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Palermo to Istanbul in May from 187€

Return flights