AirHint found the following cheapest return flights from Palermo (PMO) to Istanbul (IST) in May 2026 (see full year).

Return flights

02 May - 05 May	Air Serbia
06 May - 12 May	Ryanair
01 May - 04 May	easyJet
01 May - 05 May	easyJet
09 May - 16 May	Air Serbia
22 May - 14 Jun	easyJet
01 May - 07 May	easyJet
05 May - 10 May	easyJet
08 May - 13 May	Ryanair
08 May - 12 May	Ryanair
14 May - 19 May	Ryanair
19 May - 02 Jun	Vueling Airlines
28 May - 02 Jun	easyJet
30 May - 02 Jun	Ryanair
30 May - 06 Jun	Air Serbia
14 May - 02 Jun	Vueling Airlines
29 May - 02 Jun	easyJet
27 May - 02 Jun	Ryanair
17 May - 02 Jun	Vueling Airlines
21 May - 02 Jun	Vueling Airlines

Also check the deals for one-way flights from Palermo to Istanbul in May.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Palermo to Istanbul in May from 142€

Return flights