AirHint found the following cheapest return flights from Prestwick (PIK) to Pisa (PSA) in September 2025 (see full year).

Return flights

22 Sep - 26 Sep	Ryanair	direct
29 Sep - 03 Oct	Ryanair	direct
26 Sep - 03 Oct	Ryanair	direct
29 Sep - 06 Oct	Ryanair	direct
26 Sep - 06 Oct	Ryanair	direct
22 Sep - 06 Oct	Ryanair	direct
19 Sep - 26 Sep	Ryanair	direct
22 Sep - 25 Sep	Ryanair
26 Sep - 29 Sep	Ryanair
26 Sep - 30 Sep	Ryanair
22 Sep - 29 Sep	Ryanair
19 Sep - 22 Sep	Ryanair	direct
25 Sep - 29 Sep	Ryanair
26 Sep - 29 Sep	Ryanair	direct
19 Sep - 24 Sep	Ryanair
29 Sep - 04 Oct	Ryanair

Also check the deals for one-way flights from Prestwick to Pisa in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Prestwick to Pisa in September from 63€

Return flights