AirHint found the following cheapest return flights from Prestwick (PIK) to Prague (PRG) in December 2025 (see full year).

Return flights

07 Dec - 14 Dec	Ryanair
18 Dec - 20 Dec	Ryanair
05 Dec - 07 Dec	Ryanair
13 Dec - 14 Dec	Ryanair
18 Dec - 23 Dec	Ryanair
16 Dec - 19 Dec	Ryanair
19 Dec - 23 Dec	Ryanair
14 Dec - 20 Dec	Ryanair
05 Dec - 08 Dec	Ryanair
20 Dec - 21 Dec	Ryanair

Also check the deals for one-way flights from Prestwick to Prague in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Prestwick to Prague in December from 186€

Return flights