AirHint found the following cheapest return flights from Prestwick (PIK) to Prague (PRG) in December 2025 (see full year).

Return flights

07 Dec - 11 Dec	Ryanair
12 Dec - 14 Dec	Ryanair
15 Dec - 19 Dec	Ryanair
19 Dec - 22 Dec	Ryanair
21 Dec - 23 Dec	Ryanair
22 Dec - 28 Dec	Ryanair
08 Dec - 13 Dec	Ryanair
23 Dec - 04 Jan	Ryanair
23 Dec - 27 Dec	Ryanair
23 Dec - 03 Jan	Ryanair
23 Dec - 28 Dec	Ryanair
28 Dec - 30 Dec	Ryanair
31 Dec - 02 Jan	Ryanair
31 Dec - 04 Jan	Ryanair
28 Dec - 01 Jan	Ryanair
30 Dec - 03 Jan	Ryanair

Also check the deals for one-way flights from Prestwick to Prague in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Prestwick to Prague in December from 175€

Return flights