AirHint found the following cheapest return flights from Chicago (ORD) to Prague (PRG) in September 2025 (see full year).

Return flights

08 Sep - 15 Sep	Spirit Airlines
04 Sep - 06 Sep	Spirit Airlines
07 Sep - 14 Sep	Icelandair
14 Sep - 21 Sep	Icelandair
07 Sep - 21 Sep	Icelandair
04 Sep - 18 Sep	Spirit Airlines
29 Sep - 07 Oct	Turkish Airlines
09 Sep - 16 Sep	United
03 Sep - 10 Sep	United
23 Sep - 30 Sep	United
11 Sep - 18 Sep	United
30 Sep - 31 Oct	United
29 Sep - 06 Oct	United

Also check the deals for one-way flights from Chicago to Prague in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Chicago to Prague in September from 455€

Return flights