AirHint found the following cheapest return flights from Chicago (ORD) to Prague (PRG) in October 2025 (see full year).

Return flights

23 Oct - 06 Nov	Scandinavian Airlines
26 Oct - 09 Nov	Scandinavian Airlines
22 Oct - 28 Oct	Turkish Airlines
12 Oct - 19 Oct	Icelandair
29 Oct - 05 Nov	United
17 Oct - 21 Oct	Icelandair
15 Oct - 22 Oct	United
21 Oct - 28 Oct	United
09 Oct - 16 Oct	United
24 Oct - 31 Oct	United
18 Oct - 25 Oct	United
03 Oct - 10 Oct	United
06 Oct - 13 Oct	United

Also check the deals for one-way flights from Chicago to Prague in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Chicago to Prague in October from 403€

Return flights