AirHint found the following cheapest return flights from New York (NYC) to Santiago (SCL) in September 2025 (see full year).

Return flights

27 Sep - 29 Sep	Spirit Airlines
27 Sep - 11 Oct	Spirit Airlines
28 Sep - 11 Oct	Frontier Airlines
27 Sep - 30 Sep	Frontier Airlines
15 Sep - 25 Oct	Frontier Airlines
18 Sep - 25 Sep	Avianca
16 Sep - 23 Sep	Frontier Airlines
28 Sep - 11 Oct	Delta	direct
21 Sep - 28 Sep	Frontier Airlines
16 Sep - 23 Sep	Delta	direct
18 Sep - 25 Sep	LATAM Airlines Group	direct
27 Sep - 29 Sep	LATAM Airlines Group	direct
19 Sep - 26 Sep	LATAM Airlines Group
15 Sep - 25 Oct	Delta	direct
19 Sep - 26 Sep	Delta	direct

Also check the deals for one-way flights from New York to Santiago in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from New York to Santiago in September from 471€

Return flights