AirHint found the following cheapest return flights from Mexico City (MEX) to Santiago (SCL) in September 2025 (see full year).

Return flights

16 Sep - 22 Sep	Arajet
30 Sep - 06 Oct	Arajet
17 Sep - 22 Sep	Avianca
14 Sep - 21 Sep	Avianca
30 Sep - 11 Oct	Avianca
27 Sep - 05 Oct	Avianca
30 Sep - 07 Oct	Avianca
14 Sep - 27 Sep	Avianca
25 Sep - 29 Sep	Avianca
16 Sep - 28 Sep	Avianca
16 Sep - 21 Sep	Avianca
27 Sep - 04 Oct	Avianca
25 Sep - 02 Oct	Avianca
27 Sep - 11 Oct	Avianca
24 Sep - 01 Oct	Volaris
10 Sep - 25 Sep	Avianca
02 Sep - 05 Sep	Avianca
16 Sep - 23 Sep	Arajet
02 Sep - 07 Oct	Arajet
28 Sep - 05 Oct	Arajet

Also check the deals for one-way flights from Mexico City to Santiago in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Mexico City to Santiago in September from 381€

Return flights