AirHint found the following cheapest return flights from Mexico City (MEX) to Santiago (SCL) in September 2025 (see full year).

Return flights

16 Sep - 08 Oct	Arajet
30 Sep - 08 Oct	Arajet
16 Sep - 22 Sep	Arajet
02 Sep - 10 Sep	Arajet
25 Sep - 29 Sep	Arajet
28 Sep - 06 Oct	Arajet
28 Sep - 08 Oct	Arajet
09 Sep - 22 Sep	Arajet
14 Sep - 24 Sep	Arajet
15 Sep - 31 Oct	Volaris
11 Sep - 25 Sep	Volaris
25 Sep - 10 Oct	Arajet
18 Sep - 29 Sep	Copa
17 Sep - 24 Sep	Copa
15 Sep - 22 Sep	Copa
15 Sep - 25 Sep	Copa
23 Sep - 07 Oct	Copa
30 Sep - 07 Oct	Copa
25 Sep - 14 Oct	Copa
28 Sep - 02 Oct	Arajet

Also check the deals for one-way flights from Mexico City to Santiago in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Mexico City to Santiago in September from 387€

Return flights