AirHint found the following cheapest return flights from Mexico City (MEX) to Santiago (SCL) in September 2025 (see full year).

Return flights

25 Sep - 29 Sep	Arajet
09 Sep - 24 Sep	Arajet
11 Sep - 24 Sep	Arajet
11 Sep - 22 Sep	Arajet
04 Sep - 10 Sep	Arajet
15 Sep - 24 Sep	Avianca
11 Sep - 18 Sep	Avianca
14 Sep - 23 Sep	Avianca
15 Sep - 22 Sep	Avianca
01 Sep - 30 Sep	Avianca
30 Sep - 14 Oct	Avianca
08 Sep - 08 Oct	Avianca
16 Sep - 04 Oct	Avianca
27 Sep - 04 Oct	Avianca
26 Sep - 03 Oct	Avianca
25 Sep - 02 Oct	Avianca
25 Sep - 09 Oct	Avianca
28 Sep - 03 Oct	Avianca
30 Sep - 06 Oct	Avianca
30 Sep - 07 Oct	Avianca

Also check the deals for one-way flights from Mexico City to Santiago in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Mexico City to Santiago in September from 372€

Return flights