AirHint found the following cheapest return flights from Mexico City (MEX) to Santiago (SCL) in May 2026 (see full year).

Return flights

03 May - 13 May	Arajet
21 May - 27 May	Arajet
12 May - 20 May	Avianca
12 May - 26 May	Avianca
13 May - 25 May	Avianca
22 May - 28 May	Avianca
11 May - 20 May	Avianca
12 May - 27 May	Avianca
15 May - 29 May	Avianca
20 May - 28 May	Avianca
21 May - 10 Jun	Arajet
31 May - 10 Jun	Arajet
15 May - 01 Jun	Avianca
28 May - 12 Jun	Arajet
28 May - 12 Jun	LATAM Airlines Group	direct

Also check the deals for one-way flights from Mexico City to Santiago in May.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Mexico City to Santiago in May from 348€

Return flights