AirHint found the following cheapest return flights from Mexico City (MEX) to Santiago (SCL) in May 2026 (see full year).

Return flights

07 May - 13 May	Arajet
03 May - 13 May	Arajet
03 May - 11 May	Arajet
19 May - 27 May	Avianca
04 May - 11 May	Avianca
04 May - 08 May	Avianca
11 May - 26 May	Avianca
20 May - 24 May	Avianca
22 May - 29 May	Avianca
14 May - 21 May	Avianca
27 May - 03 Jun	Avianca
03 May - 04 Jun	Avianca
25 May - 04 Jun	Avianca
27 May - 02 Jun	Viva
22 May - 02 Jun	Viva
28 May - 02 Jun	Viva
29 May - 02 Jun	Viva
17 May - 02 Jun	Viva
22 May - 03 Jun	Viva
22 May - 04 Jun	Viva

Also check the deals for one-way flights from Mexico City to Santiago in May.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Mexico City to Santiago in May from 350€

Return flights