AirHint found the following cheapest return flights from Mexico City (MEX) to Santiago (SCL) in May 2026 (see full year).

Return flights

07 May - 13 May	Arajet
03 May - 13 May	Arajet
18 May - 22 May	Volaris
03 May - 09 May	Volaris
11 May - 17 May	Volaris
25 May - 03 Jun	Volaris
04 May - 11 May	Volaris
23 May - 30 May	Volaris
11 May - 21 May	Volaris
28 May - 04 Jun	Arajet
05 May - 26 May	Copa
01 May - 16 May	Copa
29 May - 21 Jun	Volaris
24 May - 06 Jun	Avianca
28 May - 04 Jun	LATAM Airlines Group	direct
29 May - 06 Jun	LATAM Airlines Group
27 May - 04 Jun	Viva
22 May - 04 Jun	Viva
22 May - 03 Jun	Viva
27 May - 17 Jun	Viva

Also check the deals for one-way flights from Mexico City to Santiago in May.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Mexico City to Santiago in May from 361€

Return flights