AirHint found the following cheapest return flights from Mexico City (MEX) to Panama City (PTY) in September 2025 (see full year).

Return flights

23 Sep - 25 Sep	Avianca
02 Sep - 05 Sep	Avianca
02 Sep - 04 Sep	Avianca
23 Sep - 27 Sep	Avianca
20 Sep - 27 Sep	Avianca
23 Sep - 07 Oct	Avianca
25 Sep - 02 Oct	Avianca
30 Sep - 10 Oct	Avianca
18 Sep - 23 Sep	Aeromexico	direct
19 Sep - 24 Sep	Avianca
05 Sep - 09 Sep	Aeromexico	direct
28 Sep - 05 Oct	Aeromexico	direct
01 Sep - 04 Sep	Avianca
18 Sep - 22 Sep	Avianca
29 Sep - 05 Oct	Avianca
29 Sep - 05 Oct	Copa	direct
25 Sep - 02 Oct	Copa	direct
30 Sep - 10 Oct	Copa	direct
28 Sep - 02 Oct	Avianca
23 Sep - 07 Oct	Copa	direct

Also check the deals for one-way flights from Mexico City to Panama City in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

Book a cheap hotel in Panama City

Cheap car rent in Panama City

Cheapest return flights from Mexico City to Panama City in September from 240€

Return flights