AirHint found the following cheapest return flights from Mexico City (MEX) to Guayaquil (GYE) in September 2025 (see full year).

Return flights

04 Sep - 07 Sep	Avianca
26 Sep - 29 Sep	Avianca
15 Sep - 22 Sep	Avianca
29 Sep - 06 Oct	Avianca
04 Sep - 13 Sep	Avianca
21 Sep - 29 Sep	Arajet
26 Sep - 12 Oct	Avianca
01 Sep - 08 Sep	Avianca
16 Sep - 23 Sep	Avianca

Also check the deals for one-way flights from Mexico City to Guayaquil in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Mexico City to Guayaquil in September from 302€

Return flights