AirHint found the following cheapest return flights from Chicago (MDW) to Prague (PRG) in December 2025 (see full year).

Return flights

05 Dec - 10 Dec	Delta
09 Dec - 16 Dec	Delta
09 Dec - 17 Dec	Delta
16 Dec - 10 Jan	Frontier Airlines
24 Dec - 21 Jan	Delta
22 Dec - 17 Jan	Frontier Airlines
23 Dec - 05 Jan	Frontier Airlines
23 Dec - 28 Dec	Delta
24 Dec - 27 Dec	Delta
22 Dec - 03 Jan	Frontier Airlines
18 Dec - 01 Jan	Delta
21 Dec - 31 Dec	KLM
19 Dec - 31 Dec	KLM
18 Dec - 31 Dec	Air France
23 Dec - 27 Dec	Delta

Also check the deals for one-way flights from Chicago to Prague in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Chicago to Prague in December from 483€

Return flights