AirHint found the following cheapest return flights from Chicago (MDW) to Cairo (CAI) in September 2025 (see full year).

Return flights

09 Sep - 30 Sep	Delta
15 Sep - 15 Oct	Delta
16 Sep - 16 Oct	Delta
10 Sep - 27 Sep	Delta
22 Sep - 13 Oct	Frontier Airlines
22 Sep - 14 Oct	Frontier Airlines
18 Sep - 08 Oct	Delta
20 Sep - 11 Oct	Delta
22 Sep - 12 Oct	Frontier Airlines
14 Sep - 20 Sep	Delta
21 Sep - 12 Oct	Frontier Airlines

Also check the deals for one-way flights from Chicago to Cairo in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Chicago to Cairo in September from 617€

Return flights