AirHint found the following cheapest return flights from Rio Negro (MDE) to Madrid (MAD) in September 2025 (see full year).

Return flights

07 Sep - 23 Sep	Avianca
25 Sep - 30 Sep	Avianca
23 Sep - 17 Oct	Avianca
01 Sep - 15 Sep	JetSmart
07 Sep - 21 Sep	Avianca
08 Sep - 23 Sep	Avianca
18 Sep - 17 Oct	JetSmart
07 Sep - 14 Sep	Avianca
18 Sep - 13 Oct	JetSmart
20 Sep - 07 Oct	Avianca
08 Sep - 26 Sep	Avianca
29 Sep - 26 Oct	Avianca
30 Sep - 26 Oct	Avianca
08 Sep - 30 Sep	Avianca
29 Sep - 29 Oct	Avianca
21 Sep - 07 Oct	Avianca
09 Sep - 22 Sep	Avianca
07 Sep - 30 Sep	Avianca
29 Sep - 14 Oct	Avianca
28 Sep - 20 Oct	Avianca

Also check the deals for one-way flights from Rio Negro to Madrid in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Rio Negro to Madrid in September from 643€

Return flights