AirHint found the following cheapest return flights from Rio Negro (MDE) to Madrid (MAD) in September 2025 (see full year).

Return flights

16 Sep - 23 Sep	Spirit Airlines
07 Sep - 17 Sep	Spirit Airlines
08 Sep - 17 Sep	Spirit Airlines
25 Sep - 14 Oct	Spirit Airlines
23 Sep - 06 Oct	Spirit Airlines
21 Sep - 28 Sep	Spirit Airlines
30 Sep - 14 Oct	Spirit Airlines
21 Sep - 08 Oct	JetSmart
07 Sep - 20 Sep	Copa
22 Sep - 15 Oct	Spirit Airlines
30 Sep - 26 Oct	Spirit Airlines
06 Sep - 24 Sep	Avianca
22 Sep - 29 Sep	Avianca
08 Sep - 15 Sep	Avianca
07 Sep - 14 Sep	Avianca
21 Sep - 30 Sep	Avianca
29 Sep - 07 Oct	Avianca
06 Sep - 07 Oct	Avianca
27 Sep - 05 Oct	Avianca
23 Sep - 09 Oct	Avianca

Also check the deals for one-way flights from Rio Negro to Madrid in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Rio Negro to Madrid in September from 515€

Return flights