AirHint found the following cheapest return flights from Rio Negro (MDE) to Madrid (MAD) in September 2025 (see full year).

Return flights

30 Sep - 26 Oct	Spirit Airlines
29 Sep - 10 Oct	JetSmart
13 Sep - 30 Sep	Spirit Airlines
23 Sep - 13 Oct	Spirit Airlines
24 Sep - 30 Sep	Avianca
23 Sep - 30 Sep	Avianca
23 Sep - 29 Sep	Avianca
16 Sep - 29 Sep	Spirit Airlines
17 Sep - 30 Sep	Spirit Airlines
20 Sep - 07 Oct	Avianca
22 Sep - 06 Oct	Spirit Airlines
13 Sep - 13 Oct	Spirit Airlines
14 Sep - 30 Sep	Spirit Airlines
20 Sep - 18 Oct	Avianca
19 Sep - 22 Sep	Avianca
24 Sep - 02 Oct	Avianca
26 Sep - 02 Oct	Avianca
21 Sep - 01 Oct	Copa
09 Sep - 18 Sep	Spirit Airlines
12 Sep - 23 Sep	Spirit Airlines

Also check the deals for one-way flights from Rio Negro to Madrid in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Rio Negro to Madrid in September from 641€

Return flights