AirHint found the following cheapest return flights from Rio Negro (MDE) to Madrid (MAD) in September 2026 (see full year).

Return flights

20 Sep - 14 Oct	Avianca
18 Sep - 28 Sep	Avianca	direct
20 Sep - 30 Sep	Avianca	direct
27 Sep - 18 Oct	Avianca	direct
15 Sep - 02 Oct	Avianca
16 Sep - 09 Oct	Avianca	direct
09 Sep - 23 Sep	Avianca	direct
13 Sep - 04 Oct	Avianca	direct
11 Sep - 30 Sep	Avianca	direct
11 Sep - 27 Sep	Avianca	direct
22 Sep - 20 Oct	Avianca
30 Sep - 17 Oct	Avianca
27 Sep - 17 Oct	Avianca
24 Sep - 20 Oct	LATAM Airlines Group
12 Sep - 04 Oct	Avianca
15 Sep - 22 Sep	Avianca
04 Sep - 21 Sep	LATAM Airlines Group
01 Sep - 21 Sep	Avianca
01 Sep - 15 Sep	Avianca
04 Sep - 21 Sep	Avianca	direct

Also check the deals for one-way flights from Rio Negro to Madrid in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Rio Negro to Madrid in September from 767€

Return flights