AirHint found the following cheapest return flights from Rio Negro (MDE) to Madrid (MAD) in October 2025 (see full year).

Return flights

01 Oct - 16 Oct	Avianca
15 Oct - 29 Oct	Copa
10 Oct - 26 Oct	Avianca
10 Oct - 31 Oct	Avianca
10 Oct - 28 Oct	Avianca
27 Oct - 15 Nov	Avianca
01 Oct - 17 Oct	Avianca
08 Oct - 29 Oct	Air Europa	direct
08 Oct - 28 Oct	Air Europa	direct
24 Oct - 09 Nov	TAP
21 Oct - 06 Nov	Avianca
22 Oct - 06 Nov	Avianca
08 Oct - 18 Nov	Avianca
25 Oct - 08 Nov	Wingo
08 Oct - 20 Oct	Avianca
08 Oct - 21 Oct	Avianca
25 Oct - 15 Nov	JetSmart
17 Oct - 07 Nov	Avianca	direct
12 Oct - 02 Nov	Avianca	direct
07 Oct - 05 Nov	Air Europa	direct

Also check the deals for one-way flights from Rio Negro to Madrid in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Rio Negro to Madrid in October from 703€

Return flights