AirHint found the following cheapest return flights from Rio Negro (MDE) to Madrid (MAD) in October 2025 (see full year).

Return flights

10 Oct - 26 Oct	Avianca
15 Oct - 15 Nov	Spirit Airlines
16 Oct - 31 Oct	JetSmart
01 Oct - 20 Oct	Copa
01 Oct - 16 Nov	Avianca
18 Oct - 13 Nov	Avianca
09 Oct - 23 Oct	Avianca
27 Oct - 10 Nov	Air Europa	direct
30 Oct - 06 Nov	Air Europa	direct
22 Oct - 12 Nov	Air Europa	direct
28 Oct - 11 Nov	Air Europa	direct
19 Oct - 10 Nov	Air Europa	direct
09 Oct - 30 Oct	Avianca
19 Oct - 02 Nov	Avianca
08 Oct - 25 Oct	Spirit Airlines
15 Oct - 01 Nov	Spirit Airlines
06 Oct - 10 Oct	Spirit Airlines
07 Oct - 28 Oct	Spirit Airlines
14 Oct - 21 Oct	Spirit Airlines
07 Oct - 21 Oct	Spirit Airlines

Also check the deals for one-way flights from Rio Negro to Madrid in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Rio Negro to Madrid in October from 638€

Return flights