AirHint found the following cheapest return flights from Rio Negro (MDE) to Madrid (MAD) in October 2025 (see full year).

Return flights

24 Oct - 19 Nov	Avianca
30 Oct - 11 Nov	Avianca
29 Oct - 12 Nov	Copa
26 Oct - 11 Nov	Avianca
29 Oct - 11 Nov	Copa
21 Oct - 11 Nov	Copa
19 Oct - 11 Nov	Copa
25 Oct - 15 Nov	Avianca
24 Oct - 15 Nov	Copa
22 Oct - 07 Nov	Copa
21 Oct - 31 Oct	Avianca
22 Oct - 31 Oct	Avianca
25 Oct - 26 Oct	Spirit Airlines
24 Oct - 31 Oct	Avianca
19 Oct - 22 Oct	Copa
21 Oct - 28 Oct	Avianca
19 Oct - 26 Oct	Copa
21 Oct - 29 Oct	Copa
19 Oct - 28 Oct	Avianca
24 Oct - 27 Oct	Avianca

Also check the deals for one-way flights from Rio Negro to Madrid in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Rio Negro to Madrid in October from 704€

Return flights