AirHint found the following cheapest return flights from Rio Negro (MDE) to Madrid (MAD) in October 2025 (see full year).

Return flights

07 Oct - 16 Oct	Copa
21 Oct - 30 Oct	Spirit Airlines
04 Oct - 24 Oct	Spirit Airlines
10 Oct - 05 Nov	Copa
11 Oct - 28 Oct	JetSmart
01 Oct - 20 Oct	Avianca
29 Oct - 19 Nov	JetSmart
10 Oct - 26 Oct	Copa
25 Oct - 08 Nov	JetSmart
25 Oct - 18 Nov	JetSmart
17 Oct - 03 Nov	JetSmart
29 Oct - 17 Nov	JetSmart
22 Oct - 21 Nov	JetSmart
23 Oct - 09 Nov	JetSmart
14 Oct - 09 Nov	JetSmart
21 Oct - 31 Oct	KLM
30 Oct - 20 Nov	Spirit Airlines
04 Oct - 16 Oct	Wingo
15 Oct - 29 Oct	Avianca	direct
15 Oct - 31 Oct	Avianca	direct

Also check the deals for one-way flights from Rio Negro to Madrid in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Rio Negro to Madrid in October from 603€

Return flights