AirHint found the following cheapest return flights from Rio Negro (MDE) to Sao Paulo (GRU) in December 2025 (see full year).

Return flights

03 Dec - 10 Dec	Avianca
06 Dec - 11 Dec	LATAM Airlines Group
31 Dec - 21 Jan	GOL Linhas Aéreas
29 Dec - 18 Jan	Avianca
10 Dec - 14 Dec	Wingo
01 Dec - 10 Dec	Copa
09 Dec - 15 Dec	Avianca
10 Dec - 15 Dec	Avianca
26 Dec - 02 Jan	Avianca
20 Dec - 02 Jan	Avianca
31 Dec - 13 Jan	Avianca
31 Dec - 15 Jan	Avianca
29 Dec - 13 Jan	Avianca
23 Dec - 31 Dec	Avianca
23 Dec - 03 Jan	Avianca
30 Dec - 02 Jan	GOL Linhas Aéreas
28 Dec - 06 Jan	Avianca
19 Dec - 23 Dec	Avianca
09 Dec - 26 Dec	GOL Linhas Aéreas
06 Dec - 15 Dec	Copa

Also check the deals for one-way flights from Rio Negro to Sao Paulo in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

Book a cheap hotel in Sao Paulo

Cheap car rent in Sao Paulo

Cheapest return flights from Rio Negro to Sao Paulo in December from 349€

Return flights