AirHint found the following cheapest return flights from Orlando (MCO) to Guayaquil (GYE) in September 2025 (see full year).

Return flights

17 Sep - 11 Oct	Spirit Airlines
12 Sep - 21 Sep	Spirit Airlines
12 Sep - 20 Sep	Spirit Airlines
06 Sep - 13 Sep	Spirit Airlines
06 Sep - 10 Sep	Spirit Airlines
25 Sep - 05 Oct	Spirit Airlines
19 Sep - 26 Sep	Spirit Airlines
05 Sep - 10 Sep	Spirit Airlines
18 Sep - 25 Sep	LATAM Airlines Group
28 Sep - 05 Oct	Spirit Airlines
10 Sep - 16 Sep	Spirit Airlines
15 Sep - 03 Oct	Copa
25 Sep - 28 Sep	Copa

Also check the deals for one-way flights from Orlando to Guayaquil in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Orlando to Guayaquil in September from 332€

Return flights