AirHint found the following cheapest return flights from Manchester (MAN) to Sao Paulo (GRU) in September 2025 (see full year).

Return flights

16 Sep - 30 Sep	TAP
10 Sep - 15 Oct	KLM
10 Sep - 23 Sep	Air France
12 Sep - 05 Oct	TAP
06 Sep - 18 Sep	TAP
16 Sep - 25 Sep	TAP
18 Sep - 18 Oct	TAP
22 Sep - 08 Oct	TAP
19 Sep - 10 Oct	TAP
05 Sep - 12 Sep	Vueling Airlines
08 Sep - 14 Sep	Ryanair
18 Sep - 13 Oct	TAP
11 Sep - 19 Sep	Vueling Airlines
01 Sep - 08 Sep	Ryanair
01 Sep - 15 Sep	Ryanair
10 Sep - 17 Sep	Air France

Also check the deals for one-way flights from Manchester to Sao Paulo in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Manchester to Sao Paulo in September from 661€

Return flights