AirHint found the following cheapest return flights from Madrid (MAD) to Santa Cruz (VVI) in December 2025 (see full year).

Return flights

03 Dec - 11 Dec	Avianca
28 Dec - 22 Jan	Avianca
24 Dec - 24 Jan	Avianca
08 Dec - 28 Dec	Avianca
27 Dec - 21 Jan	Avianca
24 Dec - 31 Dec	Avianca
10 Dec - 23 Jan	Avianca
28 Dec - 22 Jan	Iberia	direct
03 Dec - 11 Dec	Iberia	direct
03 Dec - 25 Dec	Iberia	direct
02 Dec - 02 Jan	Avianca
22 Dec - 29 Dec	Avianca
12 Dec - 30 Dec	Plus Ultra Lineas Aereas
10 Dec - 13 Jan	Plus Ultra Lineas Aereas
13 Dec - 26 Jan	Avianca
24 Dec - 19 Jan	Avianca
15 Dec - 19 Jan	Lufthansa
14 Dec - 31 Dec	Avianca
13 Dec - 27 Dec	Iberia
15 Dec - 22 Dec	Air Europa	direct

Also check the deals for one-way flights from Madrid to Santa Cruz in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Madrid to Santa Cruz in December from 768€

Return flights