AirHint found the following cheapest return flights from Madrid (MAD) to Santa Cruz (VVI) in December 2025 (see full year).

Return flights

27 Dec - 27 Jan	Avianca
27 Dec - 24 Jan	Avianca
27 Dec - 26 Jan	Avianca
31 Dec - 24 Jan	Air Europa
01 Dec - 06 Dec	Iberia	direct
01 Dec - 08 Dec	Iberia	direct
26 Dec - 26 Jan	Avianca
15 Dec - 27 Dec	LATAM Airlines Group
02 Dec - 09 Dec	LATAM Airlines Group
29 Dec - 21 Jan	Avianca
01 Dec - 13 Dec	Iberia	direct
31 Dec - 31 Jan	Iberia	direct
28 Dec - 22 Jan	Plus Ultra Lineas Aereas
27 Dec - 27 Jan	Air Europa	direct
24 Dec - 24 Jan	TAP
05 Dec - 08 Dec	Royal Air Maroc
01 Dec - 04 Dec	Boliviana de Aviacion	direct
01 Dec - 28 Dec	Iberia	direct
03 Dec - 27 Dec	TAP
08 Dec - 15 Dec	ITA Airways

Also check the deals for one-way flights from Madrid to Santa Cruz in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Madrid to Santa Cruz in December from 919€

Return flights