AirHint found the following cheapest return flights from Madrid (MAD) to Santa Cruz (VVI) in December 2025 (see full year).

Return flights

26 Dec - 31 Dec	Avianca
05 Dec - 26 Jan	Avianca
06 Dec - 09 Dec	Avianca
08 Dec - 22 Dec	Avianca
27 Dec - 01 Jan	Avianca
06 Dec - 21 Dec	Avianca
07 Dec - 21 Dec	Avianca
22 Dec - 29 Jan	Avianca
12 Dec - 06 Jan	Boliviana de Aviacion
14 Dec - 05 Jan	Boliviana de Aviacion
24 Dec - 14 Jan	Boliviana de Aviacion
06 Dec - 09 Dec	Air Europa	direct
08 Dec - 22 Dec	Air Europa	direct
22 Dec - 29 Dec	Avianca
22 Dec - 20 Jan	Avianca
05 Dec - 07 Jan	LATAM Airlines Group
01 Dec - 02 Jan	Avianca
29 Dec - 15 Jan	Avianca
15 Dec - 31 Dec	Avianca
20 Dec - 27 Dec	Avianca

Also check the deals for one-way flights from Madrid to Santa Cruz in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Madrid to Santa Cruz in December from 833€

Return flights