Cheapest one-way flights from Madrid to Santa Cruz in December from 445€

Best time to book flights for Madrid (MAD) to Santa Cruz (VVI) flights at AirHint

AirHint found the following cheapest one-way flights from Madrid (MAD) to Santa Cruz (VVI) in December 2025 (see full year).

One-Way flights

10 Dec LATAM Airlines Group
02 Dec LATAM Airlines Group
01 Dec LATAM Airlines Group
09 Dec LATAM Airlines Group
04 Dec LATAM Airlines Group
05 Dec LATAM Airlines Group
07 Dec LATAM Airlines Group
03 Dec LATAM Airlines Group
26 Dec LATAM Airlines Group
12 Dec LATAM Airlines Group

Also check the deals for return flights from Madrid to Santa Cruz in December.

Skyscanner

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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