AirHint found the following cheapest one-way flights from Madrid (MAD) to Santa Cruz (VVI) in December 2025 (see full year).

One-Way flights

12 Dec	Boliviana de Aviacion	direct
10 Dec	Boliviana de Aviacion	direct
09 Dec	Boliviana de Aviacion
16 Dec	Boliviana de Aviacion
23 Dec	Boliviana de Aviacion
05 Dec	Boliviana de Aviacion	direct
17 Dec	Boliviana de Aviacion	direct
24 Dec	Boliviana de Aviacion	direct
25 Dec	Avianca
26 Dec	Avianca

Also check the deals for return flights from Madrid to Santa Cruz in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

Book a cheap hotel in Santa Cruz

Cheap car rent in Santa Cruz

Cheapest one-way flights from Madrid to Santa Cruz in December from 312€

One-Way flights