AirHint found the following cheapest return flights from Madrid (MAD) to Quito (UIO) in September 2025 (see full year).

Return flights

17 Sep - 27 Oct	Avianca
18 Sep - 14 Oct	Air Europa	direct
25 Sep - 06 Oct	Delta
17 Sep - 04 Oct	Avianca
25 Sep - 28 Sep	Delta
24 Sep - 13 Oct	Delta
17 Sep - 30 Sep	Avianca
25 Sep - 07 Oct	Delta
30 Sep - 14 Oct	Air Europa	direct
26 Sep - 28 Sep	Delta
24 Sep - 28 Sep	Delta
17 Sep - 29 Sep	Avianca
17 Sep - 22 Sep	Avianca
19 Sep - 04 Oct	Avianca
20 Sep - 05 Oct	Avianca
27 Sep - 27 Oct	Avianca
19 Sep - 28 Sep	Delta
15 Sep - 21 Sep	Delta
25 Sep - 30 Sep	Avianca
15 Sep - 26 Sep	Delta

Also check the deals for one-way flights from Madrid to Quito in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Madrid to Quito in September from 629€

Return flights